基本信息
 叶非
性 别: 出生年月: 1964-04-20
职 称: 教授 工作单位: 文理学院
硕导(招生学科): 化学工程与技术 博导(招生学科): 化学生物学
办公电话: 55190070 E-mail: yefei@neau.edu.cn
 开设课程情况
课程编号 课程名称 课程类别 学时
20600021g 有机化学 本科 54
20610004g 基础化学实验 本科 96
20600022z 有机合成概论 本科 36
211203 化学文献 研究生 16
211105 应用化学学科前沿专题讲座 研究生 16
211102 精细有机合成 研究生 48
 主持科研项目概况

1. 新型卤代磺酰氧(氮)杂桥环安全剂的设计、合成及活性研究  

                                                          国家自然科学基金面上项目

2. 新型磺酰脲类除草剂的安全剂设计、制备及活性  

                                                          黑龙江省自然科学基金(重点项目)

3. 新型磺酰脲类除草剂的安全剂设计与创制 

                           哈尔滨市科技创新人才研究专项资金项目(优秀学科带头人)

4. 新型卤代甲磺酰取代氧氮杂桥环类安全剂的设计、合成及活性研究  

                                                          黑龙江省自然科学基金

 项目获奖概况

1. 基于分子碎片重组设计的农用功能分子及其作用机制研究 

                                                 黑龙江省科学技术奖(自然科学奖)二等奖  2020

2. 安全剂保护作物免受除草剂药害研究

                                                  黑龙江省科学技术奖(自然科学奖)二等奖 2016

3. 除草剂污染土壤的生物修复及作物保护

                                                  黑龙江省科学技术奖(自然科学奖)二等奖 2015

4. 基于磺酰脲类除草剂的安全剂活性与构效研究

                        黑龙江省科学技术奖(自然科学奖)三等奖 2006

 代表性著作、论文

                                             近期发表的主要论文

1. Yuan-Yuan Zhang, Shuang Gao, Minh-Tu Hoang, Zi-Wei Wang, Xin Ma, Yue Zhai, Na Li, Li-Xia Zhao, Ying Fu* and Fei Ye*  Protective efcacy of phenoxyacetyl oxazolidine derivatives as safeners against nicosulfuron toxicity in maize. Pest Management Science, 2021, 77:177-183

2. Lu Li, Shuang Gao, Liu Yang, Yu-Long Liu, Ping Li, Fei Ye*, Ying Fu*. Cobalt (II) complex as a fluorescent sensing platform for the selective and sensitive detection of triketone HPPD inhibitors. Journal of Hazardous Materials, 2021, 404:124015

3. Zi-Wei Wang, Li-Xia Zhao, Peng Ma, Tong Ye, Ying Fu*, Fei Ye*. Fragments

Fragments Recombination, Design, Synthesis, Safener Activity and CoMFA Model of Novel Substituted Dichloroacetylphenyl Sulfonamide Derivatives. Pest Management Science, 2021,77: 1724–1738

4. Ke-Liang Guo, Li-Xia Zhao, Zi-Wei Wang, Ying-Chao Gao Juan-Juan Li, Shuang Gao, Ying Fu*, Fei Ye*  Design, Synthesis and Bio-evaluation of Substituted Phenyl Isoxazole Analogues as Herbicide Safener.Journal of Agricultural and Food Chemistry, 2020,68(39):10550-10559

5. Li-xia Zhao, Jia-jun Hu, Zhi-xin Wang, Min-lei Yin, Yue-li Zou, Shuang Gao, Ying Fu*, Fei Ye* Novel phenoxy-(trifluoromethyl)pyridine-2-pyrrolidinone-based inhibitors of protoporphyrinogen oxidase: Design, synthesis, and herbicidal activity. Pesticide Biochemistry and Physiology,  2020, 170:104684

6. Shuang Gao, Yanyan Liu, Jingyu Jiang, Xiaoming Li, Lixia Zhao, Ying Fu* Fei Ye* Encapsulation of thiabendazole in hydroxypropyl-β-cyclodextrin nanobers via polymer-free electrospinning and its characterization. Pest Management Science, 2020, 76(9): 3264–3272

7. Li-Xia Zhao, Mao-Jun Jiang, Jia-Jun Hu, Yue-Li Zou, Shuang Gao, Ying Fu*, Fei Ye*. Herbicidal Activity and Molecular Docking Study of Novel PPO Inhibitors. Weed Science, 2020,68(6):565-574

8. Yong-Xuan Liu, Li-Xia Zhao, Tong Ye, Shuang Gao, Jia-Zhong Li, Fei Ye*, Ying Fu*. Identification of key residues determining the binding specificity of human 4-hydroxyphenylpyruvate dioxygenase. European Journal of Pharmaceutical Sciences,2020,154,105504

9. Li-Xia Zhao, Mao-Jun Jiang, Jia-Jun Hu, Yue-Li Zou, Yuan Cheng, Tao Ren, Shuang Gao, Ying Fu, Fei Ye*.  Design, synthesis, and herbicidal activity of novel diphenyl ether derivatives containing fast degrading tetrahydrophthalimide. Journal of Agricultural and Food Chemistry, 2020, 68, 3729-3741 (高被引论文)

10. Yuan-Yuan Zhang, Shuang Gao, Yong-Xuan Liu, Chen Wang, Wei Jiang, Li-Xia Zhao, Ying Fu*, Fei Ye*. Design, Synthesis and Biological Activity of Novel Diazabicyclo Derivatives as Safeners. Journal of Agricultural and Food Chemistry, 2020, 68, 3403-3414 (高被引论文)

11. Nan Wu, Li-Xia Zhao, Chun-Yu Jiang, Ping Li, Yulong Liu, Ying Fu*, Fei Ye*. A naked-eye visible colorimetric and fluorescent chemosensor for rapid detection of fluoride anions: Implication for toxic fluorine-containing pesticides detection. Journal of Molecular Liquids, 2020, 302:112549

12. Ying Fu, Dong Zhang, Shuai-Qi Zhang, Yong-Xuan Liu, You-Yuan Guo, Meng-Xia Wang, Shuang Gao, Li-Xia Zhao, Fei Ye*. Discovery of N-Aroyl Diketone/Triketone Derivatives as Novel 4-Hydroxyphenylpyruvatedioxygenase Inhibiting-based Herbicide. Journal of Agricultural and Food Chemistry, 2019, 67(43):11839-11847(高被引论文)

13. Fei Ye, Yue Zhai, Ke-Liang Guo, Yong-Xuan Liu, Na Li, Shuang Gao, Li-Xia Zhao, Ying Fu*. Safeners improve maize tolerance under herbicide toxicity stress by increasing the activity of enzyme in vivo. Journal of Agricultural and Food Chemistry, 2019,67(42):11568-11576

14. Ying Fu, Yong-Xuan Liu, Ke-Han Yi, Ming-Qiang Li, Jia-Zhong Li, Fei Ye*. Quantitative Structure Activity Relationship Studies and Molecular Dynamics Simulations of 2-(Aryloxyacetyl)cyclohexane-1,3-Diones Derivatives as 4- Hydroxyphenylpyruvate Dioxygenase Inhibitors. Frontiers in Chemistry, 2019,7:556(热点论文)

15. Ying Fu, Yong-Xuan Liu, Tao Kang, Yi-Na Sun, Jia-Zhong Li, Fei Ye*. Identification of novel inhibitors of p-hydroxyphenylpyruvate dioxygenase using receptor-based virtual screening. Journal of the Taiwan Institute of Chemical Engineers, 2019, 103:33-43

16. Fei Ye, Nan Wu, Ping Li, Yu-Long Liu, Shi-Jie Li, Ying Fu*. A lysosome-targetable fluorescent probe for imaging trivalent cations Fe3+, Al3+ and Cr3+ in living cells.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019,22(5):117242

17. Ying Fu, Shuai-Qi Zhang, Yong-Xuan Liu, Jing-Yi Wang, Shuang Gao, Li-Xia Zhao, Fei Ye*. Design, Synthesis, SAR and Molecular Docking of Novel Green Niacin-Triketone HPPD Inhibitor. Industrial Crops and Products, 2019,137:566-575 (热点和高被引论文)

18. Fei Ye, Yue Zhai, Tao Kang, Shi-Long Wu, Juan-Juan LiShuang Gao, Li-Xia Zhao, Ying Fu*  Rational Design, Synthesis and Structure-Activity Relationship of Novel Substituted Oxazole Isoxazole Carboxamides as Herbicide Safener. Pesticide Biochemistry and Physiology,2019,157:60-68 (高被引论文)

19. Fei Ye, Xiao-Min Liang, Ke-Xin Xu, Xiao-Xiao Pang, Qiong Chai, Ying Fu A novel dithiourea-appended naphthalimide “on-off” fluorescent probe for detecting Hg2+ and Ag+ and its application in cell imaging. Talanta, 2019,200:494–502

20. Fei Ye, Xiao-Min Liang, Nan Wu, Ping Li, Qiong Chai, Ying Fu A novel dithiourea-appended naphthalimide “on-off” fluorescent probe for detecting Hg2+ and Ag+ and its application in cell imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2019,216:359–364

21. Ying Fu, Dong Zhang, Tao Kang, You-Yuan Guo, Wen-Geng Chen, Shuang Gao, Fei Ye. Fragment splicing-based design,synthesis and safener activity of novel substituted phenyl oxazole derivatives. Bioorganic & Medicinal Chemistry Letters2019,29(4):570-576

22. Ying Fu, Kui Wang, Peng Wang, Jing-Xin Kang, Shuang Gao, Li-Xia Zhao, Fei Ye*. Design, Synthesis and Herbicidal Activity Evaluation of Novel Aryl-Naphthyl Methanone Derivatives. Frontiers in Chemistry, 2019, 7:2 (高被引论文)

23. Ying Fu, Xiao-Xiao Pang, Zhi-Qiang Wang, Qiong Chai, Fei Ye*. A highly sensitive and selective fluorescent probe for determination of Cu (II) and application in live cell imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2019,208:198-205

24. Fei Ye, Peng Ma, Yuan-Yuan Zhang, Ping Li, Fei Yang and Ying Fu*. Herbicidal Activity and MolecularDocking Study of Novel ACCase Inhibitors. Frontiers in Plant Science, 2018, 9:1850 (热点论文)

25. Ying Fu, Yi-Na Sun, Ke-Han Yi, Ming-Qiang Li, Hai-Feng, Cao, Jia-Zhong Li, Fei Ye*.  Combination of Virtual Screening Protocol by in silico towards the Discovery of Novel HPPD Inhibitors. Frontiers in Chemistry, 2018,6:14

 授权的专利等情况

1.一种N-二氯乙酰基噁唑烷类除草剂安全剂的制备方法. 发明专利 ZL200710071894.3

2.用超声波法提取苦参碱的方法. 发明专利 ZL200710071951.8

3.N-二氯乙酰基-6,7-二氯-1,2,3,4-四氢喹喔啉及其制备方法.发明专利 ZL201310196037.1

4.一种用于禾本科作物田的除草剂及其用途. 发明专利 ZL201610078256.3

5.一种用于单子叶作物的除草组合物及其应用. 发明专利 ZL201511033695.4

6. 用于玉米生长的区域防治有害杂草的除草组合物及其用途. 发明专利 ZL 201810750196.4

7. 除草组合物及其应用. 发明专利 ZL 201711383039.6

8. 一种含肉桂酰基的三酮类化合物、制备方法及其应用. 发明专利 ZL201911191742.6

9. 一种含有喹喔啉结构的三酮类化合物、制备方法及其应用. 发明专利 ZL201911193040.1

 

 其他获奖及荣誉称号

教育部霍英东青年教师三等奖

黑龙江省教学名师

黑龙江省优秀教师

教育部高等学校大学化学课程教学指导委员会委员

国家林业和草原局院校教材建设专家委员会委员

一流专业支,一流教师引领,一流课程推动化学类创新人才培养模式的改革与实践 

                                                                                    黑龙江省高等学校教学成果二等奖 2020

农业院校应用化学优秀教学团队与系列课程的建设与实践. 

                                                                                    东北农业大学教学成果一等奖 2017

农业院校应化专业系列课程数字化网络教学资源的建设与实践 

                                                                                     黑龙江省高等学校教学成果二等奖 2013

高等农业院校基础化学系列实验课程体系优化及网络辅助实验教学平台的建设.

                                          黑龙江省高等学校教学成果一等奖 2011

 农业院校绿色化学实验体系的构建与研究.          黑龙江省高等学校学成果二等奖 2009

高等农业院校基础化学实验课程体系和教学模式的创新与实践.

                                                                                    黑龙江省高等学校教学成果一等奖 2007

高等农业院校有机化学课程教学改革的研究与实践.

                                                                                    黑龙江省高等学校教学成果一等奖 2005

农业院校工科大学化学课程体系构建的研究与实践.

                                                                                    黑龙江省高等学校教学成果二等奖 2003

《基础化学实验》                  全国农业教育优秀教材 2017

《实验化学(第二版)》      全国高等农业院校优秀教材 2011

《有机化学》                          全国高等农业院校优秀教材奖    2006